Care at NUH

Division of Rheumatology and Allergy

2025/06/17
The Division of Rheumatology and Allergy provides tertiary outpatient and inpatient care to patients with autoimmune and musculoskeletal diseases. Recognised as a Centre of Excellence by the Asia Pacific League Against Rheumatism (APLAR), our aim is to deliver holistic patient care. Our rheumatologists focus on achieving disease remission, preserving function and enhancing the quality of life for our patients. Our clinical services cover a breadth of conditions in Rheumatology, Allergy and Clinical Immunology, supported by strong cross-disciplinary collaborations with Department of Medicine (which includes the various medical subspecialties including Divisions of Advanced Internal Medicine, Dermatology, Endocrinology, Gastroenterology and Hepatology, Geriatric Medicine, Infectious Diseases, Nephrology, Neurology, Rehabilitation Medicine, Respiratory and Critical Care Medicine), Haematology, Oncology, Ophthalmology, Paediatrics and Obstetrics. 

Our clinical faculty is actively involved in medical education at both undergraduate and postgraduate levels. The division serves as a site for Rheumatology Senior Residency training in Singapore and offers clinical fellowships to aspiring rheumatologists in the Asia Pacific region. The division is also a training site for Adult Allergy and Clinical Immunology.

In terms of research, the division is dedicated to translational and clinical studies, with a particular focus on systemic lupus erythematosus and inflammatory arthritis, involving local and international collaborations.  

Our Team

Head of Division & Senior Consultant

Senior Consultants

Consultants

Associate Consultant

Visiting Consultants

  • A/Prof Koh Dow Rhoon
  • Adj. Associate Professor Peter Cheung
  • Dr Anita Lim

Senior Residents

  • Dr Chong Kar Mun
  • Dr Wang Jiali

Clinical Fellows

  • Dr Yeo Chong Hsien
  • Dr Gamage Kamalika

Rheumatology Nurses

  • Assistant Nurse Clinician Chong Siew Hwa
  • Senior Staff Nurse Ginny Goh
  • Senior Staff Nurse Ruby Ong

Allergy Nurses

  • Senior Staff Nurse Serene Xu
  • Senior Staff Nurse Sylvia Oh

Honorary Nurse Clinician

  • Dr Siriwan Lim

Pharmacists

  • Jiang He
  • Elaine Lo
  • Felicia Lim
  • Cai Qizheng
Our Services

Rheumatology

Rheumatology Specialist Outpatient Clinics
Our Rheumatology specialist outpatient clinics operate daily at the Medicine Clinic at Medical Centre (Level 13). Patients receive support from our experienced nurse educators, clinic nurses and allied health staff. Joint aspiration and injection procedures may be performed if required. We provide comprehensive care for a wide range of conditions including:

Inflammatory arthritis such as rheumatoid arthritis, spondyloarthritis (e.g. ankylosing spondylitis, psoriatic arthritis, reactive arthritis and enteropathic spondyloarthritis), adult patients with juvenile idiopathic arthritis
Connective tissue disease including systemic lupus erythematous, sjögren’s syndrome, systemic sclerosis, inflammatory myositis, mixed connective tissue disease, overlap connective tissue disease
Antiphospholipid syndrome
Systemic vasculitis including takayasu’s arteritis, giant cell arteritis and polymyalgia rheumatica, polyarteritis nodosa, ANCA-associated vasculitis (granulomatous polyangiitis, microscopic polyangiitis and eosinophilic granulomatous polyangiitis), Behcet’s disease, cryoglobulinemic vasculitis
Crystal arthropathies including gout and pseudogout
Osteoporosis
Osteoarthritis
Soft tissue rheumatism
IgG4-related disease
Sarcoidosis
Relapsing polychondritis
Still’s disease
Autoinflammatory syndromes e.g. VEXAS syndrome

In addition to our general Rheumatology clinics, we offer subspecialty, multidisciplinary clinics and allied health-led clinics to provide holistic care.

Subsepecialty Clinics

Early Access Inflammatory Arthritis Clinic
Patients with suspected inflammatory arthritis are given expedited access to this clinic for early diagnosis and treatment. Point of care ultrasound and joint aspiration / injection procedures may be performed as appropriate. 

Lupus Clinic
Patients with severe systemic lupus erythematosus (SLE) may have multisystem disease requiring frequent follow-up and multidisciplinary care. This clinic provides fast-track and comprehensive care for these patients with the support of our allied health professionals. Patients are also given early-access to cutting-edge treatment including involvement in clinical trials. 

High Risk Pregnancy Clinic
Our patients with rheumatic disease are at higher risk of foetal and maternal complications during pregnancy. This clinic specialises in managing patients with rheumatic diseases who are pregnant, planning to conceive or are undergoing assisted reproductive treatments. Close partnership with Obstetrics is maintained throughout pregnancy and peri-partum to optimise care. Many of our patients have gone on to have successful pregnancies – click here to find out about one such patient who was featured on The Straits Times. 

Combined Connective Tissue Disease - Interstitial Lung Disease (CTD-ILD) Clinic 
This clinic specialises in care for patients with interstitial lung disease (ILD) associated with various connective tissue diseases (CTD). ILD consists of a diverse group of lung conditions caused by inflammation and scarring. If not treated early, patients with CTD-ILD may develop worsening symptoms (such as cough, shortness of breath and activity limitation) which can progress to respiratory failure. Patients receive coordinated care by our rheumatologist and respiratory physician in this combined clinic. Additionally, nailfold capillaroscopy may be performed.

Combined Eye-Rheumatology Clinic
This is a monthly subspecialty clinic where our rheumatologists and ophthalmologists concurrently review patients with complex autoimmune eye conditions. Holistic care is provided to prevent irreversible vision loss and manage associated co-morbidities.

Allied-Health Led Clinics 

1. Immunotherapeutics Clinic
A pharmacist-led clinic monitoring patients on medications for inflammatory and autoimmune diseases. Medications include conventional antirheumatic drugs like methotrexate and azathioprine, as well as newer biologic therapies such as monoclonal antibodies and targeted synthetic antirheumatic drugs. Our trained pharmacists closely monitor potential side effects and perform dose adjustment to optimise treatment efficacy for every patient. 

2. Gout Telemedicine Virtual Monitoring Clinic (VMC)
A pharmacist-led clinic providing virtual care for patients with gout, enabling remote monitoring and medication delivery. Blood tests may be arranged at the hospital or at the patient’s nearest polyclinic, with medication delivered to the patient’s doorstep after consultation. 

3. Rheumatology Nurse Education Clinic
Our passionate specialty nurses provide counselling and support for our Rheumatology patients to improve their disease understanding. They empower patients to better manage and cope with their condition. For selected conditions, our nurses provide additional support through a helpline service.

Specialised Services: Joint Aspiration / Injection, Musculoskeletal Ultrasound and Nailfold Capillaroscopy

Joint Aspiration / Injection Service
Our rheumatologists are skilled in performing aspiration (removing fluid) and injection procedures for various joints. Removing fluid from a swollen joint allows us to determine the cause of the swelling and aids in relieving pain. Steroid / local anaesthetic medications may be injected into the joint or surrounding soft tissue to reduce pain and inflammation. These procedures may be performed on the same day as the Rheumatology consultation as part of the diagnostic evaluation and treatment. Ultrasound-guided procedures may be performed in select situations (see below). Additionally, we provide training for our Internal Medicine residents and non-rheumatologists to gain proficiency in these procedures.

Musculoskeletal Ultrasound Service

1. Ultrasound Clinic
This weekly service offers musculoskeletal ultrasonography by our rheumatologists, aiding in the diagnosis of various inflammatory arthritis types such as rheumatoid arthritis, spondyloarthritis, crystal arthritis, and osteoarthritis. 

2. Point of Care Ultrasound
We provide bedside ultrasound service in the inpatient and outpatient settings. 

3. Ultrasound-Guided Joint Aspiration and Injection 
Our trained specialists provide ultrasound-guided joint aspiration / injection services, which may be employed in joints that are less easily accessed through the general joint aspiration / injection procedure.

Nailfold Capillaroscopy Service 
This is a fortnightly clinic where our rheumatologists perform nailfold capillaroscopy to look at the small blood vessels (capillaries) around the fingernails. This aids in evaluation of Raynaud’s phenomenon and various connective tissue diseases such as systemic sclerosis and dermatomyositis.

Immune-related Toxicity Team and CAR-T Steering Committee

Immune-related Toxicity (IrTox) Team
Immunotherapies are increasingly used in the treatment of cancers and have led to improved outcomes. However, these treatments may be complicated by immune-related adverse events (irAE) which may affect multiple organ systems and require urgent treatment. Managing these irAEs requires specialised, multidisciplinary expertise to ensure timely diagnosis and appropriate intervention. This led to the formation of the immune-related toxicity (IrTox) Team, a multidisciplinary team of physicians who provide real-time collaborative care for these patients. The team is helmed by Rheumatology and supported by Oncology (National University Cancer Institute, Singapore).

CAR-T Steering Committee 
Chimeric antigen receptor (CAR) T-cell therapy is a novel advanced treatment used in the treatment of certain cancers. It works by re-programming the body’s T cells (a type of white blood cell) to recognise and destroy cancer cells. CAR-T cell therapy has also been used to treat various autoimmune diseases by reprogramming T cells to destroy immune cells that produce autoantibodies which cause autoimmune disease. The CAR-T Steering committee is led by Rheumatology and Haematology (National University Cancer Institute, Singapore), and is dedicated to prioritising clinical trials and investigator-initiated studies of CAR-T cell therapy for the treatment of autoimmune diseases and cancer. 

Allergy and Clinical Immunology

Allergy Clinic
There is a trend for an increase in allergic diseases worldwide. This can range from mild allergies to severe allergies, which can be life threatening is not recognised and treated. 

Patients may suffer from allergies to environmental agents such as dust mite and pollen, medications, and food. The workup of allergies relies heavily on the patients’ symptoms. Hence, prior to any allergy testing, a careful history is taken to ensure that the tests are individualised to each patient. 

Testing may include skin tests (such as prick tests, intradermal and patch tests), blood tests, provocation tests, as well as exercise tests. Different agents and allergic symptoms may be tested through different modalities. 

In selected allergic disease, a treatment called immunotherapy (a process to allow the patient to better tolerate the substance that they are allergic to) may be recommended. 

Our Allergy clinics are located at Medical Centre Level 3 and are run by a multidisciplinary team of doctors, nurses and pharmacists. 

Combined Immunology Clinic
Patients with immunodeficiencies have weakened immune systems and are more susceptible to recurrent infections and autoimmune manifestations. These conditions can be present at birth (congenital) or acquired later in life. Care for this complex group of patients is provided by our immunologists in this clinic. We collaborate with the paediatric immunologists, infectious disease specialists, geneticists and respiratory doctors to ensure patients with immunodeficiencies in childhood are smoothly transited to the adult Clinical Immunology service.

Outpatient Infusion Centre (OPIC) 

Since 2009, OPIC has provided specialised infusion medications for various medical conditions. The availability of this service has allowed patients to receive their infusions without needing to be admitted to the hospital. This minimizes the time patients need to take off work. Operated by specially trained nurses, the centre has conducted over 6000 infusions and supports specialties within the Department of Medicine and beyond. OPIC is located at Medical Centre Level 3.

Our Education
The division strongly believes in education and mentorship. At the post-graduate level, we are one of three accredited sites for Rheumatology specialty training in Singapore. Our Rheumatology senior residents undergo a rigorous three-year training programme under the mentorship of excellent clinicians, inspiring educators and internationally-renown researchers. We also offer clinical fellowships to aspiring rheumatologists in the Asia Pacific region. Our graduates have gone on to become accomplished rheumatologists across all healthcare clusters in Singapore and in the region. Additionally, the division is a training site for Adult Allergy and Clinical Immunology. 

Click here for more information on the NUHS Rheumatology Senior Residency Programme.

NUHS Internal Medicine Residents gain exposure to diverse Rheumatology patients through inpatient clinical services and Rheumatology outpatient clinics. They are given opportunities to present at interdisciplinary meetings and international Rheumatology conferences. They are encouraged to perform supervised joint arthrocentesis to hone their procedural skills. Our rheumatologists also contribute as core faculty in the NUHS Internal Medicine Residency Programme and contribute to educational courses such as the joint aspiration workshop.

Our division is committed to nurturing our undergraduate students and honing their clinical acumen. Many of our educators are faculty members for the NUS Yong Loo Lin School of Medicine. Medical students are actively engaged through a structured clinical posting that spans across the spectrum of Rheumatology. Our elective programmes for both local and overseas medical students have been well-received and often oversubscribed. Medical students are welcome to participate in research with mentorship by our rheumatologists. 

We support our colleagues in other disciplines through education workshops such as the Asia Pacific Rheumatology Practice Course for non-rheumatologists and the Family Medicine Bridging Programme for Family Medicine trainees.
Our Research
The Division of Rheumatology and Allergy is actively involved in both clinical and basic science research, particularly in inflammatory arthritis and systemic lupus erythematosus. We participate in multiple clinical drug trials and clinical databases such as the Asia Pacific Lupus Collaboration (APLC), Singapore National Biologics Registry (SNBR), and others. Ongoing initiatives focus on quality improvement and value-driven outcomes in inflammatory arthritis and gout. The division is also the clinical lead for the National University of Singapore-Cambridge Cell Phenotyping Centre. 
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