Health Resources

New lease on life for girl with rare liver disease 

2024/09/23

Young Falisha Zafilin bid farewell to primary sclerosing cholangitis 
and welcomed a more fulfilling childhood thanks to an altruistic donor, 
as well as NUH doctors who successfully carried out her liver transplantation procedure.  
Issue 5 | June 2024

Subscribe todaySubscribe and ensure you don't miss the next issue!

At a tender age of six, Falisha wrestled with constant lethargy, endured hair loss and often missed schools—factors that inevitably narrowed her social circle.

Diagnosed with inflammatory bowel disease (IBD) at just two years old, her condition grew more dire when she was later diagnosed with primary sclerosing cholangitis (PSC), a rare and severe liver disease characterised by persistent inflammation, destruction and scarring of the bile ducts. Individuals afflicted with this disease may experience abdominal pain, itchy skin, diarrhoea, jaundice, fatigue and fever due to blockages, infections and inflammation of the bile ducts.

A turning point in Falisha’s life came when the generosity of an altruistic donor, combined with the dedication and expertise of a team of medical experts at the National University of Hospital (NUH), led to a successful liver transplant. Now 14, she lives a more fulfilling childhood and has developed a keen interest for drama.

Life-saving incredible care

At the heart of Falisha’s medical journey is her primary doctor, Dr S. Venkatesh Karthik, Senior Consultant, Division of Paediatric Gastroenterology, Nutrition, Hepatology and Liver Transplantation, Department of Paediatrics, Khoo Teck Puat – National University Children’s Medical Institute at NUH.

Falisha was referred to NUH in 2018 for a second opinion after a liver biopsy revealed that her condition had worsened due to PSC, which unfortunately has no cure. Treatment primarily involves managing symptoms and complications, such as treating cholangitis with antibiotics, or addressing end-stage liver damage through liver transplantation, which was what Falisha urgently needed when a third liver biopsy in 2021 indicated that her liver could function for only one more year.

After confirming her viability for a transplant, an altruistic donor stepped forward in September 2022, and Falisha underwent the transplant the month after, along with platelet transfusions after the surgery. The transplant was carried out at the National University Centre for Organ Transplantation (NUCOT) at NUH, which is the National Referral Centre for children up to the age of 21 years in need of a liver transplant for end-stage or metabolic liver disease. NUCOT is the only centre in Singapore that performs paediatric liver transplants, with patient outcomes comparable to international benchmarks.
Photo Source: The Straits Time @ SPH Media Limited.
Permission required for reproduction.

Dr Karthik’s expertise was particularly crucial in Falisha’s case, as the complexities of PSC demanded not just surgical precision but also a nuanced approach to her ongoing care. He devised a comprehensive treatment plan that balanced the immediate demands of post-transplant care with her long-term health management.

Today, Falisha’s life has transformed under Dr Karthik’s care. While still requiring regular follow-ups and care post-transplantation, she is no longer confined by frequent hospital visits. Falisha now enjoys a fuller, more vibrant life. She attends school regularly, participates actively in her drama group and pursues her growing passion for acting and scriptwriting.

“I wish to pursue drama and use drama to help others,” says Falisha.

“It’s been a gratifying experience to witness Falisha’s journey towards recovery and a new lease on life,” says Dr Karthik. 

 

Like this article? Simply subscribe to make sure you don't miss the next issue of EnvisioningHealth! 

Last updated on
Best viewed with Chrome 79.0, Edge 112.0, Firefox 61.0, Safari 11
National University Health System
  • National University Hospital
  • Ng Teng Fong General Hospital
  • Alexandra Hospital
  • Jurong Community Hospital
  • National University Polyclinics
  • Jurong Medical Centre
  • National University Cancer Institute, Singapore
  • National University Heart Centre, Singapore
  • National University Centre for Oral Health, Singapore
  • NUHS Diagnostics
  • NUHS Pharmacy
  • Yong Loo Lin School of Medicine
  • Faculty of Dentistry
  • Saw Swee Hock School of Public Health
Back to Top