Dr Anand Jeyasekharan

Designations:

Senior Consultant, Department of Haematology-Oncology, National University Cancer Institute, Singapore
Assistant Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore

Qualifications:

MBBS (CMC Vellore, India), MRCP (UK), PhD (Cantab), FAMS (Medical Oncology)

Specialties/Sub-specialties:

Haematology, Medical Oncology

Special Interests:

Lymphomas, Rare Cancers, and Targeting Genomic Instability in Cancer

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www.ncis.com.sg/

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Biosketch

Dr Jeyasekharan obtained his undergraduate medical degree from Christian Medical College Vellore, India in 2003. He then received a Gates Cambridge Scholarship towards a PhD in Oncology (2008) at the University of Cambridge UK (Gonville and Caius College). Following a junior research fellowship in Cambridge (Wolfson), he joined the National University Hospital Singapore in 2010 to complete his training in Internal Medicine and Medical Oncology.

Dr Jeyasekharan has a special interest in the treatment of lymphomas/sarcomas, as well as personalized therapy for rare and advanced cancers. He holds a joint appointment at the Cancer Science Institute, where he runs a translational cancer research laboratory. His laboratory focuses on understanding how the tumour microenvironment impacts the efficacy of chemotherapy. Dr Jeyasekharan holds multiple internal and nationally funded grants to support his research, and is a platform lead for a national translational research program in cancer through the Singapore Translational Cancer Consortium (STCC).

Awards

2021: Clinician Scientist Award Investigator, National Medical Research Council Awards
2017: Transition Award, National Medical Research Council Awards

Journals & Publications

Hoppe, M. M., P. Jaynes, F. Shuangyi, Y. Peng, S. Sridhar, P. M. Hoang, C. X. Liu, S. De Mel, L. Poon, E. H. L. Chan, J. Lee, C. K. Ong, T. Tang, S. T. Lim, C. Nagarajan, N. F. Grigoropoulos, S.-Y. Tan, S. S.-S. Hue, S.-T. Chang, S.-S. Chuang, S. Li, J. D. Khoury, H. Choi, C. H. III, A. Bottos, L. J. Gay, H. F. P. Runge, I. Moutsopoulos, I. Mohorianu, D. J. Hodson, P. Farinha, A. Mottok, D. W. Scott, J. J. Pitt, J. Chen, G. Kumar, K. Kannan, W. J. Chng, Y. L. Chee, S.-B. Ng, C. Tripodo and A. D. Jeyasekharan (2023). "Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma." Cancer Discovery OF1-OF20. doi:10.1158/2159-8290.Cd-22-0998.
Goh, J., S. De Mel, M. M. Hoppe, M. B. Mohd Abdul Rashid, X. Y. Zhang, P. Jaynes, E. Ka Yan Ng, N. A. D. B. Rahmat, Jayalakshmi, C. X. Liu, L. Poon, E. Chan, J. Lee, Y. L. Chee, L. P. Koh, L. K. Tan, T. G. Soh, Y. C. Yuen, H.-Y. Loi, S.-B. Ng, X. Goh, D. Eu, S. Loh, S. Ng, D. Tan, D. M. Z. Cheah, W. L. Pang, D. Huang, S. Y. Ong, C. Nagarajan, J. Y. Chan, J. C. H. Ha, L. P. Khoo, N. Somasundaram, T. Tang, C. K. Ong, W.-J. Chng, S. T. Lim, E. K. Chow and A. D. Jeyasekharan (2022). "An ex vivo platform to guide drug combination treatment in relapsed/refractory lymphoma." Science Translational Medicine 14(667): eabn7824. doi:doi:10.1126/scitranslmed.abn7824.
Ho, J. S. Y., B. W.-Y. Mok, L. Campisi, T. Jordan, S. Yildiz, S. Parameswaran, J. A. Wayman, N. N. Gaudreault, D. A. Meekins, S. V. Indran, I. Morozov, J. D. Trujillo, Y. S. Fstkchyan, R. Rathnasinghe, Z. Zhu, S. Zheng, N. Zhao, K. White, H. Ray-Jones, V. Malysheva, M. J. Thiecke, S.-Y. Lau, H. Liu, A. J. Zhang, A. C.-Y. Lee, W.-C. Liu, S. Jangra, A. Escalera, T. Aydillo, B. S. Melo, E. Guccione, R. Sebra, E. Shum, J. Bakker, D. A. Kaufman, A. L. Moreira, M. Carossino, U. B. R. Balasuriya, M. Byun, R. A. Albrecht, M. Schotsaert, A. Garcia-Sastre, S. K. Chanda, E. R. Miraldi, A. D. Jeyasekharan, B. R. TenOever, M. Spivakov, M. T. Weirauch, S. Heinz, H. Chen, C. Benner, J. A. Richt and I. Marazzi (2021). "TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation." Cell 184(10): 2618-2632.e2617.
Hoppe, M. M., P. Jaynes, J. D. Wardyn, S. S. Upadhyayula, T. Z. Tan, S. Lie, D. G. Z. Lim, B. N. K. Pang, S. Lim, J. P. S. Yeong, A. Karnezis, D. S. Chiu, S. Leung, D. G. Huntsman, A. S. Sedukhina, K. Sato, M. D. Topp, C. L. Scott, H. Choi, N. R. Patel, R. Brown, S. B. Kaye, J. J. Pitt, D. S. P. Tan and A. D. Jeyasekharan (2021). "Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer." EMBO Mol. Med. 13(5): e13366.
Ngoi, N., J. Lim, S. Ow, W. Y. Jen, M. Lee, W. Teo, J. Ho, R. Sundar, M. L. Tung, Y. M. Lee, E. Ngo, S. W. Lim, J. Ong, F. Lim, G. Bonney, B. Vellayappan, F. Ho, J. Tey, N. Chan, S. de Mel, M. Poon, S. Y. Lee, L. P. Koh, T. C. Liu, L. K. Tan, A. S. C. Wong, A. L. A. Wong, S. E. Lim, A. Yeoh, J. E. Wong, D. Tan, B. C. Goh, W. J. Chng, R. Soo, C. E. Chee, Y. L. Chee, S. C. Lee, A. D. Jeyasekharan for National University Cancer Institute (NCIS) (2020). "A segregated-team model to maintain cancer care during the COVID-19 outbreak at an academic center in Singapore." Ann. Oncol. 31(7): 840-843.
de Mel, S., M. B. M. Rashid, X. Y. Zhang, J. Goh, C. T. Lee, L. M. Poon, E. H. L. Chan, X. Liu, W. J. Chng, Y. L. Chee, J. Lee, Y. C. Yuen, J. Q. Lim, B. K. H. Chia, Y. Laurensia, D. Huang, W. L. Pang, D. M. Z. Cheah, E. K. Y. Wong, C. K. Ong, T. Tang, S. T. Lim, S. B. Ng, S. Y. Tan, H.-Y. Loi, L. K. Tan, E. K. Chow and A. D. Jeyasekharan (2020). "Application of an ex-vivo drug sensitivity platform towards achieving complete remission in a refractory T-cell lymphoma." Blood Cancer J. 10(1): 9.
Hoppe, M. M., R. Sundar, D. S. P. Tan and A. D. Jeyasekharan (2018). "Biomarkers for Homologous Recombination Deficiency in Cancer." J. Natl. Cancer Inst. 110(7): 704-713.
Jeyasekharan, A. D., Y. Liu, H. Hattori, V. Pisupati, A. B. Jonsdottir, E. Rajendra, M. Lee, E. Sundaramoorthy, S. Schlachter, C. F. Kaminski, Y. Ofir-Rosenfeld, K. Sato, J. Savill, N. Ayoub and A. R. Venkitaraman (2013). "A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization." Nat. Struct. Mol. Biol. 20(10): 1191-1201.
Jeyasekharan, A. D., N. Ayoub, R. Mahen, J. Ries, A. Esposito, E. Rajendra, H. Hattori, R. P. Kulkarni and A. R. Venkitaraman (2010). "DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells." Proc. Natl. Acad. Sci. U. S. A. 107(50): 21937-21942.
Ayoub, N., A. D. Jeyasekharan, J. A. Bernal and A. R. Venkitaraman (2008). "HP1-β mobilization promotes chromatin changes that initiate the DNA damage response." Nature 453(7195): 682-686.

Professional Memberships

Royal College of Physicians, London
Academy of Medicine, Singapore

2024/05/02

Doctor Details