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2024/01/25
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Dr Dedrick Chan

Photo of Dr Dedrick Chan

Designations:

  • Consultant, Division of Colorectal Surgery, Department of Surgery, National University Hospital
  • Consultant, Division of Surgical Oncology, National University Cancer Institute, Singapore
  • Consultant, Division of Colorectal Surgery, Department of Surgery, Alexandra Hospital

Qualifications:

MBBS, MMed(Surgery), MCI, MS(Coloproctology), PhD(Oxford), FRCS(England), FEBS(Coloproctology)

Specialties/Sub-specialties:

General Surgery

Clinical Disciplines/Programmes:

Colorectal Surgery, Surgery, Surgical Oncology

Special Interests:

Oncologic surgery, minimally invasive approaches, colonoscopy

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Biosketch

Dr Dedrick Chan is a Clinician-Scientist holding concurrent appointments as a Consultant with the Division of Colorectal Surgery, NUH, as well as Junior Academic Fellow with the Department of Surgery, NUS.

Dedrick underwent surgical training as a Resident with the National University Health System, before attaining specialist registration in General Surgery in 2018. He became a Fellow of the Royal College of Surgeons of Edinburgh and England, and also a Fellow of the Academy of Medicine, Singapore. 

To further his knowledge and training specifically in the field of Colorectal Surgery, he completed a Master of Surgery in Principles of Coloproctology at the University of East Anglia. He is also the first Singaporean candidate to sit for and successfully pass the European Board of Surgery examination in Coloproctology, an examination which defines the requisite competency of skills and knowledge required of a colorectal surgeon.

As a Clinician-Scientist, Dedrick investigates the molecular underpinnings of colorectal cancer, and aims to translate novel findings uncovered in the laboratory to tangible improvements in cancer outcomes for patients. He was generously funded by a National Medical Research Council Research Training Fellowship, and completed a PhD at the University of Oxford in 2023.

Dedrick's clinical and research interests synergistically revolve around colorectal cancer. As a colorectal surgeon, Dedrick introduces surgically-oriented interventions which improve cancer outcomes and the holistic patient experience. Dedrick's research builds on this clinical work, and has implications for cancer initiation, proliferation and metastasis. He seeks to understand the role which somatic driver mutations play in phenotypically normal tissue.

Awards

  • 2023 - Flashtalk Winner, 10th Annual CRUK-Oxford Centre Symposium
  • 2023 - N2CR-CSDU Career Development Fellow
  • 2020 - NMRC Research Training Fellowship (Full-time Overseas PhD)
  • 2018 - ExxonMobil Research Fellowship for Clinicians

Journals & Publications

  1. Ng AS, Chan DKH. Commonalities and differences in the mutational signature and somatic driver mutation landscape across solid and hollow viscus organs. Oncogene. 2023 Sep;42(37):2713-2724.
  2. Chan DKH, Mandal A, Hester S, Yu Z, Higgins GS, Kessler BM, Fischer R, Buczacki SJA. Biallelic FBXW7 knockout induces AKAP8-mediated DNA damage in neighbouring wildtype cells. Cell Death Discov. 2023 Jun 29;9(1):200.
  3. Chan DKH, Collins SD, Buczacki SJA. Generation and immunofluorescent validation of gene knockouts in adult human colonic organoids using multi-guide RNA CRISPR-Cas9. STAR Protoc. 2023 Jan 3;4(1):101978.
  4. Chan DKH, Buczacki SJA. Stage migration - a negative quality indicator in colon cancer management. Colorectal Dis. 2022 Feb;24(2):153-154.
  5. Lal N, Chan DKH, Ng ME, Vermeulen L, Buczacki SJA. Primary tumour immune response and lymph node yields in colon cancer. Br J Cancer. 2022 May;126(8):1178-1185.
  6. Chan DKH, Buczacki SJA. Tumour heterogeneity and evolutionary dynamics in colorectal cancer. Oncogenesis. 2021 Jul 16;10(7):53.
  7. Tan JKH, Ang JJ, Chan DKH. Enhanced recovery program versus conventional care after colorectal surgery in the geriatric population: a systematic review and meta-analysis. Surg Endosc. 2021 Jun;35(6):3166-3174.
  8. Ang JJ, Chia DKA, Chan DKH. Lymphocyte-White Cell Ratio Is a Novel Marker of Morbidity Following Colorectal Cancer Surgery. J Surg Res. 2021 Mar;259:71-78.
  9. Chan DKH, Lee SKF, Ang JJ. Indocyanine green fluorescence angiography decreases the risk of colorectal anastomotic leakage: Systematic review and meta-analysis. Surgery. 2020 Dec;168(6):1128-1137.
  10. Chan DKH, Tan KK. Stenting versus surgery in obstructed malignant colorectal cancer-a review of short and long-term results. J Gastrointest Oncol. 2020 Jun;11(3):486-490.

Professional Memberships

  • Fellow, Royal College of Surgeons of England
  • Associate Member, American Association for Cancer Research
  • Member, American Society of Colon and Rectal Surgeons

2024/06/11
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