Paediatric Blood Marrow and Transplantation Programme
2024/08/30
The Paediatric Blood and Marrow Transplantation (BMT) Programme at NUH and the National University of Singapore (NUS) was established by Professor Wong Hock Boon in 1983. It has achieved several milestones in the field since its inception. Employing a comprehensive team approach, covering areas from acute care to late effects care, the programme is dedicated to providing quality care for children diagnosed with high-risk cancers, as well as blood or immune diseases that require specialised BMT care.
Programme Clinical Director & Senior Consultant
Transplant Physician & Consultant
Donor Physician & Senior Consultant
High Risk Leukaemia (acute and certain chronic types) such as:
- Acute Lymphoblastic Leukaemia (ALL)
- Acute Myeloid Leukaemia (AML)
- Acute Mixed Phenotype Leukaemia (AMPL)
- Juvenile Myelomonocytic Leukaemia (JMML)
- Chronic Myeloid Leukaemia (CML)
High Risk Lymphoma (chemo-refractory)
Myelodysplastic Syndromes (MDS)
High Risk Solid Tumours such as:
- Neuroblastoma
- Brain Tumours
- Soft Tissue Sarcomas
Primary Immunodeficiency Disorders (PID) such as:
- Severe Combined Immune Deficiency (SCID)
- Chronic Granulomatous Disease (CGD)
- CD40 ligand deficiency
- Wiskott - Aldrich Syndrome (WAS)
- Rare disorders such as Chronic Active Epstein-Barr Virus infection (CAEBV)
Bone Marrow Failure Syndromes
- Congenital forms such as Fanconi Anaemia
- Acquired forms such as idiopathic severe aplastic anaemia
Haemoglobinopathies such as:
- Thalassaemia
- Diamond Blackfan Syndrome
- Congenital Anaemia
Hemophagocytic Lymphohistiocytosis (HLH)
Neuro-metabolic diseases such as:
- Hurler's Syndrome
- Cerebral Adrenoleukodystrophy (ALD) (early)
Autologous stem cell rescue after high dose chemotherapy
Allogeneic blood / marrow stem cell transplant
- Haploidentical Parental Donor Transplant
- Matched Sibling Donor Transplant (MSD)
- Matched Unrelated Donor Transplant (MUD)
- Mismatched Unrelated Donor Transplant (MMUD)
- Umbilical Cord Blood Transplant (UCB)
Immuno-cellular Therapy
- Donor Lymphocyte Infusion, conventional and novel
- Allogeneic natural killer (NK) cell therapy
Late Effects Clinics
1983
- Syngeneic bone marrow transplant was performed on an individual diagnosed with acute lymphoblastic leukaemia
1996
- Transplantation of bone marrow from an unrelated donor was performed on an individual diagnosed with acute myeloid leukaemia
2001
- Umbilical cord blood stem cell transplant from an unrelated donor was performed on an individual diagnosed with thalassemia
2004
- Autologous stem cell rescue was performed on an infant diagnosed with brain tumour, eliminating the need for radiotherapy
- Umbilical cord blood stem cell transplant from unrelated dual donors was performed on an individual diagnosed with CD40 Ligand deficiency
2010
- Haploidenticaldonor bone marrow transplant was performed using post-transplant Cyclophophamide
2012
- The programme is accredited by the Foundation for the Accreditation of Cellular Therapy (FACT)
- Adoptive transfer of IL2-activated natural killer (NK) cells from a parental donor to a patient was achieved for treating chemo-refractory, multiply relapsed acute myeloid leukaemia
- Transplant of T cell depleted parental haploidentical peripheral blood stem cells was performed on an individual diagnosed with acute lymphoblastic leukaemia
2013
- Adoptive transfer of parental haploidentical mesenchymal stem cells was performed for treating graft versus host disease in an individual diagnosed with lymphoma following an allogeneic transplant
